Prevention of peritoneal adhesions:A promising role for gene therapy

查看全文 作　　者：Hussein M [1]Atta

机构地区：[1]Department of Surgery,Faculty of Medicine,Minia University

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第46期,共10页

基　　金：Supported by The United States-Egypt Science and Technology Joint Fund in cooperation with United States Department of Agriculture;the Egyptian Science and Technology Development Fund under Project 739 摘　　要：Adhesions are the most frequent complication of abdominopelvic surgery,yet the extent of the problem,and its serious consequences,has not been adequately recognized.Adhesions evolved as a life-saving mecha-nism to limit the spread of intraperitoneal inflammatory conditions.Three different pathophysiological mechanisms can independently trigger adhesion formation.Mesothelial cell injury and loss during operations,tissue hypoxia and inflammation each promotes adhesion formation separately,and potentiate the effect of each other.Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation.This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions.It explores the prom-ising role of combinatorial gene therapy and vector modif ications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field. 关键词：基因治疗防粘连治疗作用预防腹膜生理机制严重程度操作过程

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Prevention of peritoneal adhesions:A promising role for gene therapy

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