Utility of co-transplanting mesenchymal stem cells in islet transplantation

查看全文 作　　者：Naoaki [1]Sakata;Masafumi [2,3]Goto;Gumpei [1]Yoshimatsu;Shinichi [1]Egawa;Michiaki [1]Unno

机构地区：[1]Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan;[2]Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan;[3]New Industry Creation Hatchery Center, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, Miyagi 980-8574, Japan

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第47期,共6页

基　　金：Supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, C: 22591513;the Uehara Memorial Foundation, NS;Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, B: 22390253, SE 摘　　要：Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function. 关键词：间充质的干细胞小岛移植骨头髓 IMMUNOMODULATORY 规章的 T 房间 ANGIOGENESIS 脉管的 endothelial 生长因素糖尿病 mellitus

相关文献

参考文献（47）
引证文献（6）
耦合文献（0）

参考文献(47)

引证文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Utility of co-transplanting mesenchymal stem cells in islet transplantation

参考文献(47)

引证文献(6)

用户提示