Chondroitinase ABC improves recovery of long sciatic nerve defects

查看全文 作　　者：Hailong [1]Yu;Liangbi [1]Xiang;Wenjing [2]Xu;Bin [2]Zhao;Yu [2]Wang;Jiang [2]Peng;Shibi [2]Lu

机构地区：[1]Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province,China;[2]Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China

出　　处：《Neural Regeneration Research》索引2012年第7卷第1期,共5页

基　　金：funded by the Liaoning Scientific Research Foundation of Doctor, No. 20101134;the Beijing Natural Science Foundation (The oriented micro-structure, double-aligned nerve-derived extracellular matrix scaffolds promote peripheral nerve long defects regeneration) 摘　　要：Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting. 关键词：硫酸软骨素酶神经缺损 ABC 雪旺氏细胞 SD大鼠肌肉收缩坐骨神经神经移植

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Chondroitinase ABC improves recovery of long sciatic nerve defects

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