Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus

查看全文 作　　者：Zhijun Dong Xiangyi Tao Xiaoxiao Fu Haibin Wang Donghua Wang Tiemin [1]Zhang

机构地区：[1]Department of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China

出　　处：《Neural Regeneration Research》索引2012年第7卷第3期,共5页

摘　　要：This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy. 关键词：糖尿病视网膜病变神经细胞凋亡糖尿病大鼠 2型糖尿病保护作用超细粉 CASPASE-3 BCL-2蛋白

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Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus

参考文献(36)

引证文献(2)

耦合文献(66)

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