Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

查看全文 作　　者：Hyung Hun [1]Kim;You Sun [1]Kim;Yun Kyung [2,3]Kang;Jeong Seop [1]Moon

机构地区：[1]Department of Internal Medicine,Seoul Paik Hospital,Inje University College of Medicine,Seoul 100-032,South Korea;[2]Department of Pathology,Seoul Paik Hospital,Inje University College of Medicine,Seoul 100-032,South Korea Hyung Hun Kim;[3]Department of Internal Medicine,Kosin University College of Medicine,Busan 602-702,South Korea

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第6期,共6页

基　　金：Supported by Grant from Inje University College of Medicine(2010) 摘　　要：AIM:To investigate the expressions of leptin and peroxisome proliferator-activated receptor γ(PPARG) in relation to body mass index(BMI).METHODS:We evaluated leptin and PPARG expression in 30 adenomas over 1 cm in size by immunohistochemical staining.In addition,clinicopathologic features including BMI were assessed.RESULTS:PPARG and leptin expression showed a strong positive correlation(P = 0.035).The average BMI of the leptin-positive group was higher than that of the leptin-negative group(25.4 ± 3.4 kg/m 2 vs 22.6 ± 2.4 kg/m 2,P = 0.018),and leptin expression was significantly correlated with high BMI(P = 0.024).Leptinexpression was more frequently observed in intermediate/high grade dysplasia than in low grade dysplasia(P = 0.030).However,PPARG expression was not correlated with BMI and grade of dysplasia.CONCLUSION:BMI has influenced on the leptin expression of colorectal adenoma.The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study. 关键词：过氧化物酶体增殖物激活受体瘦素肠腺免疫组织化学染色质量指数 BMI 病理特征平均体重

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Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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