不同浓度和温度时无机盐和尿素对抗抑郁剂药物丙咪嗪盐酸盐的胶束化行为的影响(英文)

查看全文 作　　者：KABIR-UD-[1]DIN;RUB Malik [1]Abdul;NAQVI Andleeb [1]Z. 机构地区：[1]Department of Chemistry,Aligarh Muslim University,Aligarh 202002,India 出　　处：《物理化学学报》索引2012年第28卷第4期,共7页 基　　金：supported by the Council of Scientific and Industrial Research,New Delhi,India(01(2208)/08/EMR-II) 摘　　要：In the present study we report the micellization behavior of imipramine hydrochloride(IMP)in absence and presence of different concentrations of inorganic salts(LiCl,NaF,NaCl,NaBr,and KCl)and ureas(urea and thiourea)over the temperature range from 288.15 to 303.15 K.The critical micellization concentrations(cmc)of drug and drug+additive systems were determined by conductometric technique. With increasing temperature the cmc first increases then decreases.Maximum cmc values were obtained at 293.15 K with or without additives.In presence of inorganic salts the cmc value decreases which is explained on the basis of nature and ion size of the added ion.Urea and thiourea also decrease the cmc at low concentrations(0.2 mmo·lL -1 urea and 0.1 mmo·lL -1 thiourea),but,at higher concentrations,increase in cmc is observed.The related thermodynamic parameters are also evaluated and discussed. 关 键 词：摘要 编辑部 编辑工作 读者