Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil

查看全文 作　　者：Ren'an [1]Qin;Desheng [2]Zhou;Jiajun [2]Wang;Hua [2]Hu;Yang [2]Yang;Xiaoxuan [1]Yao;Xiaopeng [2]Sun

机构地区：[1]Modem Chinese Medicine Research Institute of Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, Guangdong Province, China;[2]Department of Neurology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province China

出　　处：《Neural Regeneration Research》索引2012年第7卷第9期,共5页

基　　金：supported by the Bureau of Traditional Chinese Medicine of Guangdong Province, No. 2010463;the National Science and Technology'12~(th) Five-years'Major Special-purpose Foundation,No.2011ZX09201-201-01 摘　　要：After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein precursor in a transgenic cell model of Alzheimer's disease, with similar effects to donepezil. 关键词：阿尔茨海默氏症前体MRNA 淀粉样蛋白复方丹参片细胞模型转基因 HEK293细胞阿尔茨海默氏病

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Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil

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