Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control

查看全文 作　　者：Stefano Ginanni [1]Corradini;Flaminia [1]Ferri;Michela [1]Mordenti;Luigi [2]Iuliano;Maria [1]Siciliano;Maria Antonella [1]Burza;Bruno [3]Sordi;Barbara [3]Caciotti;Maria [3]Pacini;Edoardo [1]Poli;Adriano De [1]Santis;Aldo [4]Roda;Carolina [4]Colliva;Patrizia [5]Simoni;Adolfo Francesco [1]Attili

机构地区：[1]Gastroenterology Division,Department of Clinical Medicine,Sapienza University of Rome,Viale dell' Universita' 37;[2]Department of Medical Sciences and Biotechnology,Vascular Medicine and Atherothrombosis Laboratory,Sapienza University of Rome;[3]Direzione Sanitaria Terme di Chianciano;[4]Department of Pharmaceutical Science,Alma Mater-University of Bologna;[5]Department of Clinical Medicine,Alma MaterUniversity of Bologna

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第9期,共8页

基　　金：Supported by The Italian Thermal Scientific Research Foundation and the Italian Ministry of Instruction University and Research 摘　　要：AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone disease.METHODS:Postmenopausal women with functional dy-spepsia and/or constipation underwent a 12 d cycle of thermal (n=20) or tap (n=20) water controlled drinking.Gallbladder fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the study.Food consumption,stool frequency and body weight were recorded daily.RESULTS:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water consumption.Fasting gallbladder volume was significantly (P<0.005) smaller at the end of the study than at baseline in the TW (15.7±1.1 mL vs 20.1±1.7 mL) but not in the tap water group (19.0±1.4 mL vs 19.4±1.5 mL).Total serum BA concentration was significantly (P<0.05) higher at the end of the study than at baseline in the TW (5.83±1.24μmol vs 4.25±1.00μmol) but not in the tap water group (3.41±0.46μmol vs 2.91±0.56μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic acid.The number of pasta (P<0.001),meat (P<0.001) and vegetable (P<0.005) portions consumed during the study and of bowel movements per day (P<0.05) were significantly higher in the TW than in the tap water group.Body weight did not change at the end of the study as compared to baseline in both groups.CONCLUSION:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake. 关键词：碳酸氢钙饮用水硫酸盐控制体重胆结石风险动脉粥样硬化危险因素

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Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control

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