Synthesis,spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(Ⅱ) complexes

查看全文 作　　者：Sreekanth [1]Thota;Mohammad [1]Imran;Manasa [1]Udugula;Rajeshwar [1]Yerra;Subhas [2]S.Karki;Jan [3]Balzarini;Erik De [3]Clercq

机构地区：[1]Department of Pharmaceutical Chemistry&Toxicology,S.R.College of Pharmacy.Ananthasagar Warangal 506371,Andhra Pradesh.India;[2]Department of Pharmaceutical Chemistry,KLES College of Pharmacy,Rajajinagar,Bangalore 560010,India;[3]Rega Institute for Medical Research,Katholieke Universiteit Leuven.Minderbroedersstraat 10.B-3000 Leuven.Belgium

出　　处：《Chinese Chemical Letters》索引2012年第23卷第4期,共4页

基　　金：the correspondent A.Madhukar Reddy,S.R.College of Pharmacy,Warangal for providing the funds for carrying out the research work 摘　　要：The synthesis and spectroscopic characterization of ruthenium complexes(R-l to R-8) of the type[Ru(A)_2(B)],(where A = 1,10-phenanthroline/2,2′-bipyridine and B = 3.4.5-tri-OCH_3DPC,4-CH_3-DPC,4-N-(CH_3)_2-DPC,4-NO_2-DPC arc described. These ligands form bidentate octahedral ruthenium complexes.The title complexes were subjected to in vitro cytotoxic activity measurements against the human cancer T-lymphocyte cell lines MTT assay.In vitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.24 to 1.4μg/mL against CEM,0.44 to 1.9μg/mL against Molt4/C8.0.28 to 1.5μg/mL against L1210,0.24 to 0.98μg/mL against HL60,and 0.25 to 1.2μg/mL against BEL7402,depending the nature of the compound. 关键词：体外抗肿瘤钌配合物光谱表征合成细胞毒活性单核 T淋巴细胞 MTT法

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Synthesis,spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(Ⅱ) complexes

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