Surgical treatment of ulcerative colitis in the biologic therapy era

查看全文 作　　者：Alberto [1]Biondi;Marco [2,3]Zoccali;Stefano [1]Costa;Albert [1]Troci;Ettore Contessini-[1]Avesani;Alessandro [2]Fichera

机构地区：[1]Emergency and General Surgery Unit,Fondazione IRCCS 'Ca' Granda' Policlinico Maggiore,20122 Milan,Italy;[2]Department of Surgery,University of Chicago Medical Center,Chicago,IL 60637,United States;[3]First General Surgery Unit,Department of Surgery,Catholic University,00168 Rome,Italy

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第16期,共10页

摘　　要：Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field. 关键词：溃疡性结肠炎生物治疗手术治疗药物治疗治疗方案住院治疗风险成本抢救治疗

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Surgical treatment of ulcerative colitis in the biologic therapy era

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