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Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy

查看全文 作　　者：Khaleel R [1,2]Fareed;Irshad N [3]Soomro;Khalid [1,2]Hameed;Arvind [1,2]Arora;Dileep N [4]Lobo;Simon L [5]Parsons;Srinivasan [1,2]Madhusudan 高影响力作者 机构地区：[1]Laboratory of Molecular Oncology,Academic Unit of Oncology,School of Molecular Medical Sciences,Faculty of Medicine and Health Sciences,University of Nottingham;[2]Nottingham University Hospitals,Nottingham NG5 1PB,United Kingdom;[3]Department of Pathology,Nottingham University Hospitals,Nottingham NG5 1PB,United Kingdom;[4]Division of Gastrointestinal Surgery,Nottingham Digestive Diseases Centre,NIHR Biomedical Research Unit,Nottingham University Hospitals,Nottingham NG7 2UH,United Kingdom;[5]Department of Surgery,Nottingham University Hospitals,Nottingham NG5 1PB,United Kingdom高影响力机构 出　　处：《World Journal of Gastroenterology》索引2012年第18卷第16期,共6页高影响力期刊 摘　　要：AIM:To examine cytokeratin-18(CK-18) and caspasecleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade(TRG) response.METHODS:Formalin-fixed human gastro-oesophageal cancers were constructed into tissue microarrays.The first set consisted of 122 gastric/gastro-oesophageal cancer cases not exposed to neoadjuvant chemotherapy and the second set consisted of 97 gastric/gastrooesophageal cancer cases exposed to pre-operative platinum-based chemotherapy.Expression of CK-18 and caspase-cleaved CK-18 was investigated using immunohistochemistry.RESULTS:CK18 was commonly expressed in gastrooesophageal tumours(92.6%).Fifty-six point seven percent of tumours previously exposed to neoadjuvant chemotherapy were positive for caspase-cleaved CK-18 expression compared to only 24.6% of tumours not previously exposed to neoadjuvant chemotherapy(P = 0.009).In patients who received neoadjuvant chemotherapy,caspase-cleaved cytokeratin-18 expression correlated with favourable TRG response(TRG 1,2 or 3,P = 0.043).CONCLUSION:This is the largest study to date of CK-18 and caspase-cleaved CK-18 expression in gastrooesophageal tumours.We provide the first evidence that caspase-cleaved CK-18 predicts tumour regression with neoadjuvant chemotherapy. 关 键 词：细胞角蛋白 蛋白酶 食管癌 肿瘤 化疗 胃癌 CASPASE 回归
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