Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis

查看全文 作　　者：Yanbo [1]Liu;Chunming [1]Miao;Zhenjiang [1]Wang;Xin [1]He;Weigao [1]Shen

机构地区：[1]Beihua University Faculty of Medicine,Jilin 132013,Jilin Province,China

出　　处：《Neural Regeneration Research》索引2012年第7卷第12期,共8页

基　　金：supported by the Natural Science Foundation of Jilin Province,No.2011146,2012150;the Natural Science Foundation of Jilin Technology Division,No.201133139 and 201032235 摘　　要：A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed.Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro.In addition,treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo.Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma. 关键词：SURVIVIN 小干扰RNA 细胞凋亡神经母细胞瘤生长诱导 SURVIVIN RNA干扰技术

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Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis

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