Comparison of sequential and 7-,10-,14-d triple therapy for Helicobacter pylori infection

查看全文 作　　者：Hyuk Soon [1]Choi;Hoon Jai [1]Chun;Sang Hoon [1]Park;Bora [1]Keum;Yeon Seok [1]Seo;Yong Sik [1]Kim;Yoon-Tae [1]Jeen;Soon Ho [1]Um;Hong Sik [1]Lee;Chang Duck [1]Kim;Ho Sang [1]Ryu

机构地区：[1]Division of Gastroenterology and Hepatology,Department of Internal Medicine,Institute of Digestive Disease and Nutrition,Korea University College of Medicine,Seoul 136-705,South Korea

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第19期,共6页

摘　　要：AIM:To compare the effectiveness of sequential therapy for Helicobacter pylori(H.pylori) infection with that of triple therapy of varying durations.METHODS:The 460 patients enrolled in this study had H.pylori-associated gastritis or a gastric or duodenal ulcer.After screening,H.pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7,10 or 14 d,or a new 10-d sequential therapy.Each of the 4 treatment groups included 115 patients.The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology.RESULTS:The overall eradication rate was 81.0%,and eradication rates were 75.7% for 7-d conventional triple therapy,81.9% for 10-d conventional triple therapy,84.4% for 14-d conventional triple therapy,and 82.0% for 10-d sequential therapy.Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy(P = 0.416 and P = 0.405,respectively).CONCLUSION:There are no significant differences between 10-d sequential eradication therapy for H.pylori and any duration of standard triple treatment in Korean patients. 关键词：疗法三联感染幽门螺旋杆菌幽门螺杆菌十二指肠协议分析治疗

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Comparison of sequential and 7-,10-,14-d triple therapy for Helicobacter pylori infection

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