Association Analysis between a Polymorphism in the 5' Regulatory Region of the IL-6 Gene and Litter Size in Pigs

查看全文 作　　者：Lu Yang Jinluan Fu Yanfeng Fu Aiguo [1]Wang

机构地区：[1]College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture & National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China

出　　处：《Journal of Animal Science and Biotechnology》索引2011年第2卷第4期,共5页

基　　金：supported by National Natural Science Foundation of China ( No.31172176 );China Agriculture Research System ( No.CARS-36 ) 摘　　要：The aim of this study was to determine the effects of an IL-6 gene polymorphism,discovered in the 5' regulatory region,on porcine litter size.An association analysis was performed between the polymorphism and total number born(TNB) and number born alive(NBA) in 421 sows.The polymorphism was at Hpy188I within the 5' regulatory region of IL-6 gene.Three genotypes of AA,AG,and GG were detected in Landrace,and two genotypes,AA and AG,were detected in Yorkshire and Duroc pigs.The A allele was the superior allele in all three breeds,with allele frequencies ranging from 0.901 to 0.993.The IL-6 genotype was highly significantly associated with TNB and NBA in the third and following parities(P<0.01),and with total parities(P<0.05).In general,the TNB and NBA showed a tendency of GG>AG>AA,indicating that the common allele was the least favorable for litter size.Thus,there is an enormous opportunity to increase litter size if this effect is confirmed in other studies. 关键词：IL-6基因基因多态性总产仔数关联分析调控区母猪基因型检测等位基因

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Association Analysis between a Polymorphism in the 5' Regulatory Region of the IL-6 Gene and Litter Size in Pigs

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