Interaction between curcumin and mimetic biomembrane

查看全文 作　　者：CHEN [1]GuiFang;CHEN [1]YangYang;YANG [2]NaNa;ZHU [3]XueJun;SUN [2]LiZhou;LI [1,3]GenXi

机构地区：[1]Laboratory of Biosensing Technology,School of Life Sciences,Shanghai University,Shanghai 200444,China;[2]Department of Obstetrics,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036,China;[3]Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China

出　　处：《Science China(Life Sciences)》索引2012年第55卷第6期,共6页

基　　金：supported by the National Science Fund for Distinguished Young Scholars(Grant No.20925520);the National Natural Science Foundation of China(Grant No.81070511);the Leading Academic Discipline Project of Shanghai Municipal Education Commission(Grant No.J50108) 摘　　要：Curcumin,a major bioactive compound in turmeric,has a broad spectrum of antioxidant,anticarcinogenic,antimutagenic and anti-inflammatory properties.At the molecular level,curcumin modulates many structurally unrelated membrane proteins through several signaling pathways.Curcumin has been suggested to change the properties of cell membranes and affect the membrane-bound proteins indirectly;however,the detailed mechanism has yet to be investigated.In this paper,self-assembled bilayer lipid membranes are artificially constructed on the surface of a gold electrode to mimic biomembranes,and interaction between the supported membranes and curcumin is studied electrochemically.Results show that curcumin interacts with the membranes strongly,in a concentration-dependent manner.At low concentrations,curcumin tends to insert into the outer monolayer only,while at high concentrations,it may also begin to penetrate the inner monolayer.The results obtained in this work may enhance our understanding of the effect of curcumin,and possibly flavonoids,on cell membranes and membrane proteins. 关键词：相互作用姜黄素生物膜浓度依赖性模仿黄酮类化合物活性物质分子水平

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Interaction between curcumin and mimetic biomembrane

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