Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure

查看全文 作　　者：Jufang [1]Huang;Lihong [1]Zhou;Hui [1]Wang;Jia [1]Luo;Kun [1]Xiong;Leping [1]Zeng;Dan [1]Chen

机构地区：[1]Department of Anatomy and Neurobiology,Xiangya School of Medicine,Central South University,Changsha 410013,Hunan Province,China

出　　处：《Neural Regeneration Research》索引2012年第7卷第16期,共7页

基　　金：sponsored by the Ph.D.Programs Foundation of the Ministry of Education of China,No20090162110019;the Natural Science Foundation of Hunan Province,No. 10JJ4023;the Fundamental Research Funds for the Central Universities of China,No. 2011QNZT128;Graduate Scientific Research Innovation Projects of Hunan Province in 2011,No. CX2011B047 摘　　要：A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye.Synaptophysin expression was increased in the inner plexiform layer at 2 hours following injury,and was widely distributed in the outer plexiform layer at 3-7 days,and then decreased to the normal level at 14 days.This suggests that expression of this presynaptic functional protein experienced spatiotemporal alterations after elevation of intraocular pressure.There was no significant change in the fluorescence intensity and distribution pattern for synapse-associated protein 102 following elevated intraocular pressure.Synapse-associated protein 102 immunoreactivity was confined to the outer plexiform layer,while synaptophysin immunoreactivity spread into the outer plexiform layer and the outer nuclear layer at 3 and 7 days following injury.These alterations in presynaptic elements were not accompanied by changes in postsynaptic components. 关键词：突触素眼压时空元素改建视网膜生理盐水相关蛋白

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Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure

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