Relationship between Dyslipidemia and Gene Polymorphism in Tibetan Population

查看全文 作　　者：ZHANG Ling [1]Xia;SUN [2]Ying;LIANG [2]Yu;LI [2]Kui;CHEN [3]Yong;[3]GUSANGLAMU;WANG [2]Jian

机构地区：[1]Institute of Tuberculosis, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China;[2]Beijing Institute of Genomics of Chinese Academy of Sciences, Airport Industry B6, Beijing 101300, China,' 3. The;[3]ThePeople's Hospital of the Tibet Autonomous Region, Lasha 850000, Tibet, China

出　　处：《Biomedical and Environmental Sciences》索引2012年第25卷第3期,共6页

摘　　要：Objective To inves gate the rela onship between SNPs reported in previous studies and the blood lipid level in the Tibetan popula on.Methods Random cluster sampling was employed in 5 areas (Lhasa,Shigatse,Shannan,Nagqu,and Nyingchi).The levels of cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),and low-density lipoprotein cholesterol (LDL-C) from blood samples were determined and DNA was extracted for genotyping and sta s cal analyses.Results Among 1 318 subjects aged >18 years enrolled in this study,367 had dyslipidemia with a prevalence of 27.8%,of whom dyslipidemia males accounted for 33.1% and dyslipidemia females 24.5%.Results of the correla on analysis between all SNPs and TG showed that the SNPs of rs714052 and rs964184 were related to the serum TG level.Subjects with rs714052 CC genotype had the lowest TG level,and the highest TG level was found in those with rs714052 TT genotype.The serum TG level in individuals with TC genotype lied in between the above two popula on groups.Subjects with rs964184 CC genotype had the lowest TG level,and the highest serum TG level was noted in those with rs964184 GG genotype.Conclusion Several SNPs were found to be related to the serum TG level in the Tibetan popula on.The APOA5 gene and MLXIPL gene may be closely associated with the serum TG level in this ethnic popula on group. 关键词：基因多态性血脂异常人口单核苷酸多态性高密度脂蛋白胆固醇低密度脂蛋白胆固醇血脂水平西藏

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Relationship between Dyslipidemia and Gene Polymorphism in Tibetan Population

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