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Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats:Modulatory Effects of Selenium and/or Vitamin E

查看全文 作　　者：Ibtissem Ben [1]AMARA;Nejla [1]SOUDANI;Afef [1]TROUDI;Ahmed [2]HAKIM;Khaled Mounir [2]ZEGHAL;Tahia [3]BOUDAWARA;Najiba [1]ZEGHAL 高影响力作者 机构地区：[1]Animal Physiology Laboratory,Faculty of Science,BP1171,3000 Sfax,University of Sfax,Tunisia;[2]Laboratory of Pharmacology,Faculty of Medicine,3029 Sfax,University of Sfax Tunisi;[3]Anatomopathology Laboratory,CHU Habib Bourguiba 3029 Sfax,University of Sfax,Tunisia高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2012年第25卷第3期,共12页高影响力期刊 摘　　要：Objective To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate,an organophosphorus compound.Methods Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water),dimethoate+selenium (0.5 mg/kg of diet),dimethoate+vitamin E (100 mg/kg of diet),or dimethoate+selenium+vitamin E.Results Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde,protein carbonyl groups and advanced oxidation protein products.An increase in glutathione peroxidase,superoxide dismutase,catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities,glutathione,non-protein thiols and vitamins C levels were observed.Histopathological changes in lung tissue were noted as emphysema,hemorrhages and hemosiderin deposits.Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments.The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage.Conclusion We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants. 关 键 词：组织病理变化 维生素E 氧化损伤 乐果 鼠肺 调节作用 成年 WISTAR大鼠
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