Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension

查看全文 作　　者：Zhihong [1]Wu;Layi [2]Wang;Shike [1]Hou

机构地区：[1]Department of Ophthalmology, General Hospital of Chinese People's Armed Pofice Forces, Beijing 100039, China;[2]Ningbo Eye Hospital, Ningbo 315000, Zhejiang Province, China

出　　处：《Neural Regeneration Research》索引2012年第7卷第19期,共5页

基　　金：supported by the China Post-doctoral Foundation(The protective effect of αB-crystallin on retinal ganglial cells in glaucoma),No.20080430444 摘　　要：Increased endogenous αB-crystallin protein levels have been shown to reduce cell apoptosis,although the effects of exogenous αB-crystallin protein remain poorly understood.The present study established an acute ocular hypertension model in the right eye of Sprague-Dawley rats.Fluorogold retrograde tracing and immunofluorescence methods showed that the number of retinal ganglion cells decreased in the right eyes and caspase-3 expression increased following acute ocular hypertension.Intravitreal injection of αB-crystallin in the right eye increased the number of retinal ganglion cells and reduced caspase-3 expression.Results demonstrated that exogenous αB-crystallin protein inhibited caspase-3 expression and improved retinal ganglion cell survival following acute ocular hypertension. 关键词：视网膜神经节细胞蛋白水平细胞存活 SD大鼠晶状体 caspase-3 眼压急性

相关文献

参考文献（17）
引证文献（4）
耦合文献（51）

参考文献(17)

引证文献(4)

耦合文献(51)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension

参考文献(17)

引证文献(4)

耦合文献(51)

用户提示