维普中文期刊产品整合服务

Yizhijiannao Granule and a combination of its effective monomers,icariin and Panax notoginseng saponins,inhibit early PC12 cell apoptosis induced by beta-amyloid(25-35)

查看全文 作　　者：Ting [1]Zhang;Zhanwei [2]Zhang;Keli [1]Dong;Guangcheng [1]Li;Hong [1]Zhu 高影响力作者 机构地区：[1]Department of Traditional Chinese Medicine,Xiangya Third Hospital,Central South University,Changsha 410013,Hunan Province,China;[2]Department of Neurosurgery,First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan Province,China高影响力机构 出　　处：《Neural Regeneration Research》索引2012年第7卷第24期,共6页高影响力期刊 摘　　要：One of our previous studies showed that Yizhijiannao Granule,a compound Chinese medicine, effectively improved the clinical symptoms of Alzheimer's disease.In the present study,we established a model of Alzheimer's disease using beta-amyloid(25-35)in PC12 cells,and treated the cells with Yizhijiannao Granule and its four monomers,i.e.,icariin,catechin,Panax notoginseng saponins,and eleutheroside E.Flow cytometry showed that Yizhijiannao Granule-containing serum, icariin,Panax notoginseng saponins,and icariin+Panax notoginseng saponins were protective against beta-amyloid(25-35)-induced injury in PC12 cells.Icariin in combination with Panax notoginseng saponins significantly inhibited early apoptosis of PC12 cells with beta-amyloid (25-35)-induced injury compared to icariin or Panax notoginseng saponins alone.The effects of icariin+Panax notoginseng saponins were similar to the effects of Yizhijiannao Granule.The findings indicate that two of the effective monomers of Yizhijiannao Granule,icariin and Panax notoginseng saponins,can synergistically inhibit early apoptosis of PC12 cells induced by beta-amyloid(25-35). 关 键 词：β-淀粉样蛋白 PC12细胞 细胞凋亡 淫羊藿甙 颗粒相 皂甙 三七 单体
相关文献

参考文献(22)

引证文献(3)

耦合文献(87)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费