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Influence of catgut implantation at acupoints on leptin and insulin resistance in simple obesity rats

查看全文 作　　者：Runhu [1]Yan;Xiaoming [2]Liu;Jie [3]Bai;Jiang [3]Yu;Jinsong [3]Gu 高影响力作者 机构地区：[1]College of Cosmetology Medicine of DalianMedical University; Research institute of Integrated Tradi-tional and Western Medicine of Dalian Medical University,Dalian 116044, China;[2]Dermatology of The First Affiliated Hospitalof Dalian Medical University, Dalian 116011, China;[3]Jiang Yu, Jinsong Gu, College of Cosmetology Medicine of Dalian Medical University, Dalian 116044, China高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2012年第32卷第3期,共5页高影响力期刊 基　　金：Supported by Science Research Projects of Colleges and Universities of Liaoning Provincial Committee of Education (Project number:05L121) 摘　　要：OBJECTIVES:To investigate the influence of catgut implantation at acupoints on leptin resistance(LR) and insulin resistance(IR) in the simple obesity rat.METHODS:Rats were made obese with high-fat diets,after which surgical catgut was implanted at Zusanli(ST 36) and Neiting(ST 44) acupoints once a week for 4 weeks(implantation group).Rats from the implantation group were compared with normal rats and unoperated obese rats(control group).Gene expression of the leptin receptor(OB-R) was evaluated using RT-PCR and northern blot.Serum and hypothalamus leptin and insulin(INS) levels were determined by radioimmunoassay.Body weight,Lee's index,body fat,serum and hypothalamus leptin and INS levels,and hypothalamic OB-R gene expression were determined before and after treatment.RESULTS:Body weights,Lee's index,body fat,and serum leptin and INS levels were significantly higher in obese than in normal rats.Hypothalamic leptin and INS levels and OB-R gene expression were significantly lower in obese rats.Catgut implantation at acupoint promoted weight loss and decreased serum leptin and INS levels.Hypothalamic leptin and INS levels and OB-R gene expression increased significantly.CONCLUSIONS:Catgut implantation at acupoint adjusts central and peripheral leptin and promotes hypothalamic OB-R gene expression.This may be an important method for regulation of LR,IR and abnormal endocrinology and metabolism. 关 键 词：胰岛素抵抗 瘦素受体 大鼠 肥胖 穴位 线对 NORTHERN杂交 OB-R基因
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