Donation after cardio-circulatory death liver transplantation

查看全文 作　　者：Hieu Le [1]Dinh;Arnaud de [1]Roover;Abdour [2]Kaba;Séverine [2]Lauwick;Jean [2]Joris;Jean [3]Delwaide;Pierre [1]Honoré;Michel [1]Meurisse;Olivier [1]Detry

机构地区：[1]Department of Abdominal Surgery and Transplantation, University Hospital of Liège, University of Liège, 4000 Liège, Belgium;[2]Department of Anesthesia and Intensive Care Medicine, University Hospital of Liège, University of Liège, 4000 Liège, Belgium;[3]Department of Hepatology and Gastroenterol-ogy, University Hospital of Liège, University of Liège, 4000 Liège, Belgium

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第33期,共16页

摘　　要：The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT. 关键词：循环系统肝移植死亡率缺血再灌注损伤移植器官肺调制策略 DCD

相关文献

参考文献（177）
引证文献（7）
耦合文献（3）

参考文献(177)

引证文献(7)

耦合文献(3)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Donation after cardio-circulatory death liver transplantation

参考文献(177)

引证文献(7)

耦合文献(3)

用户提示