Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection

查看全文 作　　者：Giuliana [1]Sereni;Francesco [1]Azzolini;Lorenzo [1]Camellini;Debora [2]Formisano;Francesco [1]Decembrino;Veronica [1]Iori;Cristiana [1]Tioli;Maurizio [1]Cavina;Francesco Di [3]Mario;Giuliano [1]Bedogni;Romano [1]Sassatelli

机构地区：[1]Unit of Gastroenterology and Digestive Endoscopy, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, 42123 Reggio Emilia, Italy;[2]Statistics and Clinical Epidemiology Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, 42123 Reggio Emilia, Italy;[3]Unit of Gastroenterology, Ospedale S. Maria di Ca' Foncello, 31100 Treviso, Italy

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第33期,共7页

摘　　要：AIM: To determine the efficacy of our therapeutic strategy for Helicobacter pylori (H. pylori) eradication and to identify predictive factors for successful eradication. METHODS: From April 2006 to June 2010, we retrospectively assessed 2428 consecutive patients (1025 men, 1403 women; mean age 55 years, age range 18-92 years) with gastric histology positive for H. pylori infection referred to our unit for 13-C urea breath test(UBT), after first-line therapy with proton pump inhibitor (PPI) b.i.d. + amoxicillin 1 g b.i.d. + clarithromycin 500 mg b.i.d. for 7 d. Patients who were still positive to UBT were recommended a second-line therapy (PPI b.i.d. + amoxicillin 1 g b.i.d. + tinidazole 500 mg b.i.d. for 14 d). Third choice treatment was empirical with PPI b.i.d. + amoxicillin 1 g b.i.d. + levofloxacin 250 mg b.i.d. for 14 d. RESULTS: Out of 614 patients, still H. pylori-positive after first-line therapy, only 326 and 19 patients respectively rechecked their H. pylori status by UBT after the suggested second and third-line regimens. 'Per protocol' eradication rates for first, second and thirdline therapy were 74.7% (95% CI: 72.7%-76.4%), 85.3% (95% CI: 81.1%-89.1%) and 89.5% (95% CI: 74.9%-103%) respectively. The overall percentage of patients with H. pylori eradicated after two treatments was 97.8% (95% CI: 97.1%-98.4%), vs 99.9% (95% CI: 99.8%-100%) after three treatments. The study found that eradication therapy was most effective in patients with ulcer disease (P < 0.05, P = 0.028), especially in those with duodenal ulcer. Smoking habits did not significantly affect the eradication rate. CONCLUSION: First-line therapy with amoxicillin and clarithromycin produces an H. pylori eradication rate comparable or superior to other studies and secondline treatment can still be triple therapy with amoxicillin and tinidazole. 关键词：幽门螺旋杆菌治疗方案感染情况根除疗效阿莫西林质子泵抑制剂平均年龄

相关文献

参考文献（42）
引证文献（4）
耦合文献（76）

参考文献(42)

引证文献(4)

耦合文献(76)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection

参考文献(42)

引证文献(4)

耦合文献(76)

用户提示