Novel insight into mechanisms of cholestatic liver injury

查看全文 作　　者：Benjamin L [1]Woolbright;Hartmut [1]Jaeschke

机构地区：[1]Department of Pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center,Kansas City,KS 66160,United States

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第36期,共9页

基　　金：Supported by The National Institutes of Health grants,R01 DK070195 and R01 AA12916,to Jaeschke H;the 'Training Program in Environmental Toxicology',T32 ES007079-26A2 from the National Institute of Environmental Health Sciences 摘　　要：Cholestasis results in a buildup of bile acids in serum and in hepatocytes.Early studies into the mechanisms of cholestatic liver injury strongly implicated bile acidinduced apoptosis as the major cause of hepatocellular injury.Recent work has focused both on the role of bile acids in cell signaling as well as the role of sterile inflammation in the pathophysiology.Advances in modern analytical methodology have allowed for more accurate measuring of bile acid concentrations in serum,liver,and bile to very low levels of detection.Interestingly,toxic bile acid levels are seemingly far lower than previously hypothesized.The initial hypothesis has been based largely upon the exposure of μmol/L concentrations of toxic bile acids and bile salts to primary hepatocytes in cell culture,the possibility that in vivo bile acid concentrations may be far lower than the observed in vitro toxicity has far reaching implications in the mechanism of injury.This review will focus on both how different bile acids and different bile acid concentrations can affect hepatocytes during cholestasis,and additionally provide insight into how these data support recent hypotheses that cholestatic liver injury may not occur through direct bile acid-induced apoptosis,but may involve largely inflammatory cell-mediated liver cell necrosis. 关键词：肝细胞损伤损伤机制胆汁酸淤积期体外细胞毒性细胞信号转导现代分析方法细胞凋亡

相关文献

参考文献（103）
引证文献（27）
耦合文献（62）

参考文献(103)

引证文献(27)

耦合文献(62)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Novel insight into mechanisms of cholestatic liver injury

参考文献(103)

引证文献(27)

耦合文献(62)

用户提示