Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis

查看全文 作　　者：Gulseren [1]Seven;Adel [2]Assaad;Thomas [3]Biehl;Richard A [1]Kozarek

机构地区：[1]Digestive Disease Institute,Virginia Mason Medical Center,Seattle,WA 98101,United States;[2]Department of Pathology,Virginia Mason Medical Center,Seattle,WA 98101,United States;[3]Department of General,Thoracic and Vascular Surgery,Virginia Mason Medical Center,Seattle,WA 98101,United States

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第36期,共3页

摘　　要：Ulcerative jejunoileitis is an uncommon clinical syndrome consisting of abdominal pain,weight loss associated with diarrhea,and multiple inflammatory ulcerations and strictures of the small bowel.Ulcerative jejunoileitis can complicate established celiac disease or develop in patients de novo.Increased levels of tumor necrosis factor-alpha(TNF-α) in the small intestine of patients with untreated celiac disease are associated with a role in the immune pathogenesis of this disorder.No specific therapy has been shown to change the course of ulcerative jejunoileitis.We report a case of severe ulcerative jejunoileitis previously unresponsive to traditional therapies,including high dose corticosteroids and cyclosporine.The patient had a dramatic resolution of symptoms and a complete normalization of endoscopic findings after anti-TNF-α monoclonal antibody,infliximab(Remicade). 关键词：肿瘤坏死因子-α 单克隆抗体溃疡性回肠炎空肠 TNF-α 发病机制综合征

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Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis

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