维普中文期刊产品整合服务

Increased hippocampal Disrupted-In-Schizophrenia 1 expression in mice exposed prenatally to lead

查看全文 作　　者：Yuanyuan [1]You;Liguang [1]Sun;Bo [2]Peng;Yan [3]Li;Songbin [4]Ben;Shuang [5]Gao 高影响力作者 机构地区：[1]Department of Biochemical and Molecular Biology, China Medical University, Shenyang 110001, Liaoning Province, China;[2]Outpatient Department of China Medical University, Shenyang 110001, Liaoning Province, China;[3]Department of Biochemical and Molecular Biology, Jilin Medical College, Jilin 132013, Jilin Province, China;[4]School of Life Science, Liaoning University, Shenyang 110036, Liaoning Province, China;[5]School of Public Health, China Medical University, Shenyang 110001, Liaoning Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2012年第7卷第25期,共7页高影响力期刊 基　　金：supported by the National Nature Science Foundation of China, No. 39970651;a Foundation from China Medical University 摘　　要：Disrupted-In-Schizophrenia 1 is a susceptibility gene for schizophrenia and other psychiatric dis-orders. Developmental lead exposure can cause neurological disorders similar to hyperactivity dis-order, dyslexia and schizophrenia. In the present study, we examined the impact of developmental lead exposure, administered in vitro and in vivo, on hippocampal Disrupted-In- Schizophrenia 1 expression. Our results show that in cultured hippocampal neurons, in vitro exposure to 0.1-10 μM lead, inhibited neurite growth and increased Disrupted-In-Schizophrenia 1 mRNA and protein ex-pression dose-dependently. In addition, blood lead levels in mice were increased with increasing mouse maternal lead (0.01-1 mM) exposure. Hippocampal neurons from these mice showed a concomitant increase in Disrupted-In-Schizophrenia 1 mRNA and protein expression. Overall our findings suggest that in vivo and in vitro lead exposure increases Disrupted-In-Schizophrenia 1 ex-pression in hippocampal neurons dose-dependently, and consequently may influence synapse formation in newborn neurons. 关 键 词：精神分裂症 海马神经元 小鼠 神经系统疾病 产前 蛋白表达 mRNA 铅暴露
相关文献

参考文献(37)

引证文献(1)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费