The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population

查看全文 作　　者：Xinrong [1]Li;Ning [1,2]Sun;Yong [1]Xu;Yanfang [1]Wang;Suping [1]Li;Qiaorong [1]Du;Juyi [1]Peng;Jinxiu [1]Luo;Kerang [1]Zhang

机构地区：[1]Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China;[2]Nursing College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China

出　　处：《Neural Regeneration Research》索引2012年第7卷第25期,共7页

基　　金：supported by the National Natural Science Foundation of China,No. 30770770,30971054,and81171290;Science Foundation for the Youth of Shanxi,No.2011021036-1 摘　　要：The norepinephrine transporter plays an important role in the pathophysiology and pharmacological treatment of major depressive disorder.Consequently,the norepinephrine transporter gene is an attractive candidate in major depressive disorder research.In the present study,we evaluated the depression symptoms of subjects with major depressive disorder,who were all from the North of China and of Han Chinese origin,using the Hamilton Depression Scale.We examined the rela-tionship between two single nucleotide polymorphisms in the norepinephrine transporter,rs2242446 and rs5569,and the retardation symptoms of major depressive disorder using quantitative trait testing with the UNPHASED program.rs5569 was associated with depressed mood,and the GG genotype may be a risk factor for this;rs2242446 was associated with work and interest,and the TT genotype may be a risk factor for loss of interest.Our findings suggest that rs2242446 and rs5569 in the norepinephrine transporter gene are associated with the retardation symptoms of depression in the Han Chinese population. 关键词：去甲肾上腺素中国汉族人群蛋白基因抑郁症转运体症状单核苷酸多态性危险因素

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The norepinephrine transporter gene is associated with the retardation symptoms of major depressive disorder in the Han Chinese population

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