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Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia

查看全文 作　　者：Hyun Chul [1]Lim;Sang In [1]Lee;Jiande DZ [2]Chen;Hyojin [1]Park 高影响力作者 机构地区：[1]Department of Internal Medicine,Yonsei University College of Medicine,Seoul 120-752,South Korea;[2]Division of Gastroenterology,Department of Internal Medicine,University of Texas Medical Branch,Galveston,TX 77555,United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2012年第18卷第41期,共9页高影响力期刊 摘　　要：AIM:To evaluate the effect of prokinetic drugs on electrogastrography(EGG) parameters according to symptomatic changes in patients with functional dyspepsia(FD).METHODS:Seventy-four patients with FD were prospectively enrolled in this study between December 2006 and December 2010.We surveyed the patients using a questionnaire on dyspeptic symptoms before and after an 8-wk course of prokinetic drug treatment.We also measured cutaneous pre-prandial and postprandial EGG recordings including percentage of gastric waves(normogastria,bradygastria,tachygastria),dominant frequency(DF),dominant power(DP),dominant frequency instability coefficient(DFIC),dominant power instability coefficient(DPIC),and the ratio of post-prandial to fasting in DP before and after the 8-wk course of prokinetic drug treatment.RESULTS:Fifty-two patients(70%) achieved symptomatic improvement after prokinetic drug treatment.Patients who had normal gastric slow waves showed symptom improvement group after treatment.Postprandial DF showed a downward trend in the symptom improvement group,especially in the itopride group.Post-prandial DP was increased regardless of symptom improvement,especially in the itopride group and mosapride group.Post-prandial DFIC and DPIC in the symptom improvement group were significantly increased after the treatment.The EGG power ratio was increased after treatment in the symptom improvement group(0.50 ± 0.70 vs 0.93 ± 1.77,P = 0.002),especially in the itopride and levosulpiride groups.CONCLUSION:Prokinetics could improve the symptoms of FD by regulating gastric myoelectrical activity,and EGG could be a useful tool in evaluating the effects of various prokinetics. 关 键 词：不良症状 药物治疗 治疗功能 消化不良 稳定系数 功率比 问卷调查 莫沙必利
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