Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome

查看全文 作　　者：Keita [1]Fukuyama;Yasuhide [1]Ishikawa;Tetsuro [2]Ogino;Hidenobu [1]Inoue;Ryoya [1]Yamaoka;Tetsuro [1]Hirose;Tomohiko [1]Nishihira

机构地区：[1]Department of Gastroenterological Surgery,Takamatsu Red Cross Hospital,Takamatsu 760-0017,Japan;[2]Department of Pathology,Takamatsu Red Cross Hospital,Takamatsu 760-0017,Japan

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第41期,共4页

摘　　要：This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine. 关键词：小肠黏膜坏死性酸中毒肌病脑病酸性综合征乳

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Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome

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