Experimental study on anaphylaxis of Qingkailing injection and its components on Beagle dogs

查看全文 作　　者：Zhiguo [1]Wang;Danqiao [1]Wang;Yu [1]Sui;Haifeng [1]Cui;Youhua [1]Yu

机构地区：[1]Medical Experiment Center,China Academy of Chinese Medical Sciences

出　　处：《Journal of Traditional Chinese Medicine》索引2012年第32卷第4期,共5页

基　　金：Supported by National Science and Technology Major Projects(No.2010ZX09502-002) 摘　　要：OBJECTIVE:To study the anaphylaxis of Qingkailing injection(QI) and its components.METHODS:Experimental anaphylactoid and allergic reactions were used.Changes in the behaviors of Beagles and serum levels of histamine,immunoglobulin(Ig)E,IgG,IgM,eosinophil cationic protein(ECP),and interleukin(IL)-4,as well as blood pressure,after injecting QI and its components on the forelimb veins of Beagles were observed.RESULTS:According to comprehensive determination of abnormal behavior scores and changes in serum levels of histamine,IgE,IgG,IgM,ECP,and IL-4,as well as in blood pressure,radix isatidis and hyodeoxycholic acid caused anaphylactoid reactions,and honeysuckle,radix isatidis,hydrolysate,cholic acid and Gardenia jasminoides caused allergic reactions.The anaphylaxis of QI involved anaphylactoid and allergic reactions.CONCLUSION:QI and its components need to be refined further to improve the safety,efficacy,and quality of its use in clinical settings. 关键词：清开灵注射液过敏反应 BEAGLE犬组件实验 IGM抗体过敏性反应猪去氧胆酸

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Experimental study on anaphylaxis of Qingkailing injection and its components on Beagle dogs

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