Cathodic adsorptive stripping voltammetry of an anti-emetic agent Granisetron in pharmaceutical formulation and biological matrix

查看全文 作　　者：Rajeev [1]Jain;Ramkishor [1]Sharma

机构地区：[1]School of Studies in Chemistry, Jiwaji University

出　　处：《Journal of Pharmaceutical Analysis》索引2012年第2卷第6期,共7页

摘　　要：Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode (HMDE) in the potential range from -1.3 to -1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 50-200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50-225 ng/mL with detection limit 11.75 ng/mL. 关键词：吸附溶出伏安法药物制剂生物基质固相萃取技术呕吐阴极方波伏安法循环伏安法

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Cathodic adsorptive stripping voltammetry of an anti-emetic agent Granisetron in pharmaceutical formulation and biological matrix

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