Changes in secretory pathway Ca^(2+)-ATPase 2 following focal cerebral ischemia/reperfusion injury

查看全文 作　　者：Tonglin [1]Lu;Zhiping [1]Hu;Liuwang [1]Zeng;Zheng [1]Jiang

机构地区：[1]Department of Neurology, Second Xiangya Hospital, Central South University

出　　处：《Neural Regeneration Research》索引2013年第8卷第1期,共7页

基　　金：supported by the National Natural Science Foundation of China,No.81171239;Frontier Research Project of Central South University in China,No.2177-721500065;the Graduate Degree Thesis Innovation Foundation of Central South University in China 摘　　要：This study aimed to investigate changes in secretory pathway Ca2+-ATPase 2 expression following cerebral ischemia/reperfusion injury, and to define the role of Ca2+-ATPases in oxidative stress. A rat model of cerebral ischemia/reperfusion injury was established using the unilateral middle cerebral artery occlusion method. Immunohistochemistry and reverse transcription-PCR assay results showed that compared with the control group, the expression of secretory pathway Ca2+-ATPase 2 protein and mRNA in the cerebral cortex and hippocampus of male rats did not significantly change during the ischemic period. However, secretory pathway Ca2+-ATPase 2 protein and mRNA expression reduced gradually at 1, 3, and 24 hours during the reperfusion period. Our experimental findings indicate that levels of secretory pathway Ca2+-ATPase 2 protein and mRNA expression in brain tissue change in response to cerebral ischemia/reperfusion injury. 关键词：缺血再灌注损伤钙ATP酶分泌途径大鼠脑 MRNA表达水平逆转录PCR 大脑皮质蛋白质

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Changes in secretory pathway Ca^(2+)-ATPase 2 following focal cerebral ischemia/reperfusion injury

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