Recent advances in two-photon imaging: technology developments and biomedical applications

查看全文 作　　者：Yu [1]Chen;Hengchang [1,2]Guo;Wei [1,3]Gong;Luye [2]Qin;Hossein [2]Aleyasin;Rajiv R [2]Ratan;Sunghee [2]Cho;Jianxin [3]Chen;Shusen [3]Xie

机构地区：[1]Fischell Department of Bioengineering, University of Maryland, College Park,MD 20742, USA;[2]Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains,NY 10605, USA;[3]Institute of Laser and Optoelectronics Technology, Fujian Normal University

出　　处：《Chinese Optics Letters》索引2013年第11卷第1期,共8页

基　　金：H. Guo andY. Chen are supported by National Institutes of Health(NIH)under Grant Nos.R21AG042700,R21DK088066,and R21EB012215;L. Qin and S. Cho are supported by NIH under Grant No.R01HL082511;H. Aleyasin and R. R. Ratan are supported by NIH under Grant Nos.P01AG14930-10,NS04059,and NS39170; W. Gong, J.Chen, and S. Xie are supported by the National Natural Science Foundation of China under Grant No.60678054 摘　　要：In the past two decades, two-photon microscopy (TPM) transforms biomedicalresearch, allowing nondestructive high-resolution fluorescent molecular imaging and label-free imaging in vivo and in real time. Here we review the recent advances of TPM technologyincluding novel laser sources, new image acquisition paradiams, and microendoscopicimaging systems. Then, we survey the capabilities of TPM imagingof biological relevant molecules such as nicotinamideadenine dinucleotide (NADH), flavin adenine dinucleotide (FAD),and reactive oxygen species (ROS). Biomedical applications of TPM in neuroscience and cancer detection are demonstrated. 关键词：双光子显微镜生物医学应用成像技术医学领域黄素腺嘌呤二核苷酸分子成像 TPM 实时成像

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Recent advances in two-photon imaging: technology developments and biomedical applications

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