N^6 -methyl-adenosine (m^6 A) in RNA: An Old Modification with A Novel Epigenetic Function

查看全文 作　　者：Yamei [1]Niu;Xu [1,2]Zhao;Yong-Sheng [1]Wu;Ming-Ming [1,2]Li;Xiu-Jie [3]Wang;Yun-Gui [1,2]Yang

机构地区：[1]Disease Genomics and Individualized Medicine Laboratory,Beijing Institute of Genomics,Chinese Academy of Sciences;[2]University of Chinese Academy of Sciences;[3]Institute of Genetics and Developmental Biology,Chinese Academy of Sciences

出　　处：《Genomics, Proteomics & Bioinformatics》索引2013年第11卷第1期,共10页

基　　金：supported by the China 973 programs (Grant No.2011CB510103 and 2012CB518302) awarded to YGY;the CAS Innovation Program for Young Scientists to YN;the CAS '100-talents' Professor Program to YGY;the National Natural Science Foundation of China (Grant No. 30900724 and 81071648) to YN 摘　　要：N6 -methyl-adenosine (m6A) is one of the most common and abundant modifications on RNA molecules present in eukaryotes. However, the biological significance of m6A methylation remains largely unknown. Several independent lines of evidence suggest that the dynamic regulation of m6A may have a profound impact on gene expression regulation. The m6A modification is catalyzed by an unidentified methyltransferase complex containing at least one subunit methyltransferase like 3 (METTL3). m6A modification on messenger RNAs (mRNAs) mainly occurs in the exonic regions and 3'-untranslated region (3'-UTR) as revealed by high-throughput m6A-seq. One significant advance in m6A research is the recent discovery of the first two m6A RNA demethylases fat mass and obesity-associated (FTO) gene and ALKBH5, which catalyze m6A demethylation in an a-ketoglutarate (a-KG)-and Fe2+-dependent manner. Recent studies in model organisms demonstrate that METTL3, FTO and ALKBH5 play important roles in many biological processes, ranging from development and metabolism to fertility. Moreover, perturbation of activities of these enzymes leads to the disturbed expression of thousands of genes at the cellular level, implicating a regulatory role of m6A in RNA metabolism. Given the vital roles of DNA and histone methylations in epigenetic regulation of basic life processes in mammals, the dynamic and reversible chemical m6A modification on RNA may also serve as a novel epigenetic marker of profound biological significances. 关键词：mRNA 腺苷基因表达调控生物学意义改造甲基化酶组蛋白甲基化新陈代谢

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N^6 -methyl-adenosine (m^6 A) in RNA: An Old Modification with A Novel Epigenetic Function

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