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The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala

查看全文 作　　者：Haixia [1]Long;Bing [1]Liu;Bing [1]Hou;Chao [2]Wang;Jin [1]Li;Wen [3]Qin;Dawei [3]Wang;Yuan [4]Zhou;Keith M. [2]Kendrick;Chunshui [3]Yu;Tianzi [1,2,5]Jiang 高影响力作者 机构地区：[1]LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences;[2]Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China;[3]Department of Radiology, Tianjin Medical University General Hospital;[4]Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences;[5]Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia高影响力机构 出　　处：《Neuroscience Bulletin》索引2013年第29卷第1期,共12页高影响力期刊 基　　金：supported by the National Key Basic Research and Development Program(973)(2011CB707800);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300);the Natural Science Foundation of China(91132301and81000582);the Beijing Nova Program(2010B06) 摘　　要：The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications. 关 键 词：等位基因频率 中国汉族 额叶皮层 焦虑症 杏仁核 连通性 抑郁症 白种人
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