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Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients

查看全文 作　　者：Hui-yan [1]ZHANG;Jian-yong [2]WANG;Gui-shuang [3]YING;Li-ping [2]SHEN;Zhe [4]ZHANG 高影响力作者 机构地区：[1]Hangzhou Vocational & Technical College;[2]Department of Ophthalmology,the First Affiliated Hospital,School of Medicine,Zhejiang University;[3]Center for Preventive Ophthalmology and Biostatistics,Department of Ophthalmology,Perelman School of Medicine,University of Pennsylvania;[4]Department of Endocrinology,the First Affiliated Hospital,School of Medicine,Zhejiang University高影响力机构 出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》索引2013年第14卷第5期,共8页高影响力期刊 基　　金：Project (No. 2011C33029) supported by the Zhejiang Provincial Technology Application Research Planning Grant, China 摘　　要：Objective: To investigate the association of serum lipids and other risk factors with diabetic retinopathy (DR) in Chinese type 2 diabetic patients. Methods: Five hundred and twenty-three type 2 diabetic patients underwent ophthalmic examination by experienced retinal specialists to assess their DR. Serum lipids, including triglycerides, total cholesterol, high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC), were measured using Roche automated clinical chemistry analyzers. The concentration of very low density lipoprotein cholesterol (VLDLC) was calculated based on total cholesterol, HDLC and LDLC. Hyperlipidemia was defined as a total cholesterol concentration of 6.2 mmol/L or higher or the use of lipid-lowering medications. The association of risk factors with any DR or proliferative diabetic retinopathy (PDR) was assessed using the odds ratio (OR) and its 95% confidence interval (CI), calculated from logistic regression models. Results: In multivariate logistic regression models, hyperlipidemia (OR=2.39, 95% CI: 1.02-5.66), higher VLDLC (OR=1.59, 95% CI: 1.14-2.23), and higher triglyceride (OR=1.18, 95% CI: 1.03-1.37) were associated with increased risk of DR. A longer diabetic duration was associated with increased risk of DR (P<0.0001) and PDR (P=0.002) in a dose-response manner. Higher systolic blood pressure (P=0.02) and higher serum creatinine (P=0.01) were independently associated with increased risk of DR, and female gender was associated with increased risk of PDR (P=0.03). Conclusions: Among Chinese type 2 diabetic patients, hyperlipidemia, higher VLDLC, and higher triglyceride were independently associated with increased risk of DR, suggesting control of serum lipids may decrease the risk of DR. 关 键 词：Diabetic retinopathy Serum lipids Risk factors
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