Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome:a randomized,placebo-controlled trial

查看全文 作　　者：Yi [1]Chen;De-yu [2]Fu;Yu [3,4]Chen;Yan-ming [3]He;Xiao-dong [1]Fu;Yan-qiu [3]Xu;Yi [1]Liu;Xiao-tao [1]Feng;Teng [3,4]Zhang;Wen-jian [1,4]Wang

机构地区：[1]Institute of Integrative Medicine,Huashan Hospital,Fudan University;[2]Yueyang Hospital of Integrated Traditional Chinese and western Medicine,Shanghai University of Traditional Chinese Medicine;[3]Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine;[4]Clinical Research Institute of Integrative Medicine,Shanghai University of Traditional Chinese Medicine

出　　处：《Journal of Integrative Medicine》索引2013年第11卷第3期,共11页

基　　金：supported by grants from the National Traditional Chinese Medicine Administration Bureau, China;the project of Science and Technology Commission of Shanghai Municipality(No.08dj 1400600),Shanghai;the National Natural Science Foundation(No.81001574) 摘　　要：BACKGROUND:Patients with hypertension coupled with metabolic syndrome(MetS) are among the high risk population in cardiovascular and cerebrovascular diseases.To reduce the prevalence of cardiovascular and cerebrovascular diseases,it is essential to appropriately control blood pressure together with other cardiovascular risk factors. OBJECTIVE:The current study was designed to investigate the therapeutic effects on blood pressure,blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula,a compound traditional Chinese herbal medicine,in addition to routine treatment to hypertensive patients coupled with MetS. DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:A total of 43 patients with hypertension coupled with MetS were recruited into this study.The enrolled patients were randomly divided into the Chinese herbal formula group(anti-hypertensive drugs plus Yiqi Huaju Formula,CHF) and the control group(anti-hypertensive drugs plus placebo).The CHF group enrolled 22 patients while the control group received 21 cases.Treatments were given for 12 weeks in both groups. MAIN OUTCOME MEASURES:Parameters examined include 24-hour ambulatory blood pressure monitoring,body mass index,waist circumference,waist-to-hip ratio,homeostatic model assessment for insulin resistance(HOMA-IR),fasting glycosylated hemoglobin(HbA1c),fasting plasma glucose,2-hour postprandial plasma glucose(PPG),fasting plasma insulin,serum lipid,etc. RESULTS:Compared with the control group,the CHF group had significant improvement (PO.01) in anthropometric parameters,FPG,HOMA-IR,blood pressure amplitude,blood pressure variability and blood pressure load. CONCLUSION:This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors.The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention. TRIAL REGISTRATION IDENTIFIER:ChiCTR-TRC-11001633. 关键词：高血压患者代谢综合征对照试验中国益气随机公式心血管疾病

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Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome:a randomized,placebo-controlled trial

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