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Evaluation of the toxicity of fluorine in Antarctic krill on soft tissues of Wistar rats

查看全文 作　　者：ZHANG [1,2]Ling;LU [1,2]Xiaoqi;WANG [1,2]Zhangmin;QIN [3]Liqiang;YUAN [1,2]Linxi;YIN [1,2]Xuebin 高影响力作者 机构地区：[1]School of Earth and Space Science, University of Science and Technology of China;[2]Suzhou Key Lab for Eco-safety and Human Health, Suzhou Institute for Advanced Study, University of Science and Technology of China;[3]Department of Nutrition and Food Hygiene, School of Public Health, Soochow University高影响力机构 出　　处：《Advances in Polar Science》索引2013年第24卷第2期,共5页高影响力期刊 基　　金：financial support provided by the Open Research Fund from the SOA Key Laboratory for Polar Science,China (Grant no.KP201106) 摘　　要：Antarctic krill are a potential food source for humans and animals, but krill are known to contain high levels of fluorine (F). In this study, we investigated the toxicity of F in Antarctic krill using Wistar rats. There were three experimental groups: The control group were fed a basal diet, the krill treatment group were fed the same basal diet mixed with krill powder (150 mg·kg-1 F), and the sodium fluoride (NaF) treatment group were fed the basal diet with added NaF (150 mg·kg-1 F). General toxicity indicators including body weight and food intake were measured during the experiment. After three months the rats were dissected and tissue samples were collected from the liver, kidney, spleen, brain, and testis. Morphological changes in the cells of these tissues were assessed using HE staining. There were no significant differences in the body weight, the food intake, or the viscera coefficients among the three groups. In both treatment groups some pathological changes were observed in all soft tissue samples except the testis, although there were fewer and less severe pathological changes in the krill treatment group than in the NaF treatment group. The results showed that the toxicity of F in Antarctic krill was lower than for an equivalent amount of F in NaF, but it was still toxic to rats consuming large quantities of krill. The findings of this study highlight the need for further investigation into potential F toxicity if krill is to be used for human consumption. 关 键 词：Wistar大鼠 南极磷虾 毒性评价 氟化钠 软组织 食物摄入量 基础日粮 混合饲喂
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