Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat

查看全文 作　　者：Donghua [1]Li;Xin [2]Xu;Ruiya [3,4]Qian;Jianguo [1]Geng;Yan [1]Zhang;Xiaolei [1]Xie;Yasong [1]Wang;Xiaoli [1]Zou

机构地区：[1]School of Traditional Chinese Medicine,Capital Medical University;[2]Beijing Hospital ofTraditional Chinese Medicine;[3]Beijing Obstetrics and Gynecology Hospital;[4]Capital Medical University Beijing Maternaland Child Health Care Hospital,Beijing 100026,China

出　　处：《Journal of Traditional Chinese Medicine》索引2013年第33卷第2期,共5页

基　　金：Supported by Beijing City Natural Science Fund (No.7082015);National Natural Science Fund (No. 81073096);'Middle-young Aged Core Talent Cultural Plant' of Beijing City University Talent Strengthening Education Plant (No.PHR201008403) 摘　　要：OBJECTIVE:To study on effects of Lichong decoction on expression of apoptosis-controlling genes,Bcl-2 and Bcl-2-associated X protein(Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model rat.METHODS:Fifty Wistar female rats were randomly divided into a normal group,a model group,a Lichong decoction group,a Guizifuling capsule group and a Mifepristone group.The hysteromyoma rat model was established by intraperitoneal injection of exogenous estrin and progestogens.Pathological examination of uterine tissue,uterine coefficient and uterine transverse diameter were made under optic microscope and expressions of Bcl-2 and Bax mRNAs in uterine tissue in the groups were detected with real-time fluorescent quantitative polymerase chain reaction(PCR) technique.RESULTS:After treatment,under microscope it was found that in the Lichong decoction group myometrium thinned,muscle fiber slightly overgrowth or long and thin,regular arrangement,inserting phenomenon of inner circular muscle and external longitudinal muscle was occasionally or not seen in the Lichong decoction group.The uterine coefficient and the uterine transverse diameter significantly decreased(P<0.01),and Bcl-2 mRNA expression significantly decreased(P<0.01) and Bax mRNA expression significantly increased in hysteromyoma tissue(P<0.01) in the Lichong decoction group as compared with the model group.CONCLUSION:Therapeutic effects of Lichong decoction on hysteromyoma is related with decrease of Bcl-2 mRNA expression and increase of Bax mRNA expression. 关键词：BCL-2基因 mRNA表达子宫肌瘤大鼠模型模型组蛋白荧光定量聚合酶链反应 BAX基因

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Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat

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