Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression

查看全文 作　　者：Hu [1]Xiao;Dechang [1]Wang;Ran [1]Huo;Yibing [1]Wang;Yongqiang [1]Feng;Qiang [1]Li

机构地区：[1]Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University

出　　处：《Neural Regeneration Research》索引2013年第8卷第17期,共6页

基　　金：supported by the Shandong Excellent Young Scientist Research Award Fund of the Natural Science Foundation of Shandong Province, No. BS2009YY043;Shandong Medical and Health Science and Technology Development Program for Youth Fund, No. 2009QZ023;the National Natural Science Foundation of China, No. 81272099 摘　　要：This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension. 关键词：神经生长因子机械张力背部皮肤神经再生增生性瘢痕免疫组织化学免疫印迹分析 S100

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Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression

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