Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats

查看全文 作　　者：Yuefen [1]Wang;Ya [2]Xu;Yanshu [3]Pan;Weihong [4]Li;Wei [5]Zhang;Yang [3]Liu;Jing [3]Jia;Pengtao [1]Li

机构地区：[1]Department of Encephalopathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine;[2]Department of Basic Chinese Medicine, School of Basic Medical Sciences, Beijing University of Chinese Medicine;[3]Pathology Room, Department of Human Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine;[4]Medical Comprehensive Course Teaching Center, School of Basic Medical Sciences, Beijing University of Chinese Medicine;[5]Anatomy Room, Department of Human Morphology, School of Basic Medical Sciences, Beijing University of Chinese Medicine

出　　处：《Neural Regeneration Research》索引2013年第8卷第18期,共11页

基　　金：financially supported by the National Science and Technology Major Project for New Drug Creation Program by the Ministry of Science and Technology No.2009ZX09502-014 摘　　要：Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts (containing 1.5 g/kg crude drug) or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition, there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract. 关键词：去卵巢大鼠记忆能力牛膝学习酶联免疫吸附试验谷胱甘肽过氧化物酶超氧化物歧化酶乙醇提取物

相关文献

参考文献（72）
引证文献（4）
耦合文献（312）

参考文献(72)

引证文献(4)

耦合文献(312)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats

参考文献(72)

引证文献(4)

耦合文献(312)

用户提示