肥胖肿瘤的关联机制-潜在可能的研究方向(英文)

查看全文 作　　者：Chunjun [1]Sheng;Ruoxue [2]Li;Peng [1]Yang;Shen [1]Qu;Zheng [3]Cui;Kun [1]Lu

机构地区：[1]Department of Endocrinology,Shanghai Tenth People's Hospital,Tongji University School of Medicine;[2]Renji Hospital,Shanghai Jiaotong University School of Medicine;[3]Comprehensive Cancer Center,Wake Forest University School of Medicine

出　　处：《The Chinese-German Journal of Clinical Oncology》索引2013年第12卷第8期,共6页

摘　　要：Recently, obesity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease. There is more and more sufficient evidence that excess body weight is an avoidable cause of excess cancers including gastrointestinal, endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal cancers. The mechanism that obesity association with cancer is remains not well understood. There be some most studied hypothesized mechanisms such as, high levels of insulin and free levels of insulin-like growth factors (IGFs), sex hormones, adipocytokines, inflammatory cytokines, c-Myc (or Myc) oncogenic transcription factor, obesity-induced hypoxia and Warburg effect, and so on. In the future, the potential mechanisms and conclusions in obesity associated with increased risk for developing cancer, and the underlying cellular and molecular mechanisms will be studied. 关键词：癌症肥胖关联关系胰岛素样生长因子 C-MYC基因分子机制细胞因子心血管疾病

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肥胖肿瘤的关联机制-潜在可能的研究方向(英文)

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