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Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke

查看全文 作　　者：Lianqiu [1]Min;Shuai [2]Shao;Xiaoning [1]Wu;Lin [3]Cong;Ping [4]Liu;Haiping [4]Zhao;Yumin [4]Luo 高影响力作者 机构地区：[1]Department of Neurology,First Affiliated Hospital of Liaoning Medical University;[2]Department of Neurology,Liaoyang Central Hospital;[3]Department of Neurology,Fuxin No.2 People's Hospital;[4]Research Institute of Cerebrovascular Diseases,Xuanwu Hospital of Capital Medical University高影响力机构 出　　处：《Neural Regeneration Research》索引2013年第8卷第23期,共11页高影响力期刊 基　　金：supported by the Natural Science Foundation of Liaoning Province in China,No.20092192;the National Natural Science Foundation of China,No.81071058 摘　　要：Atorvastatin decreases inflammation and thrombogenesis in patients with carotid artery plaque. Atorvastatin is administered to lower lipid levels, but its anti-inflammatory and anti-thrombogenic effects remain unclear. Eighty-nine patients from northeastern China with acute ischemic stroke caused by large-artery atherosclerosis were randomly divided into the study and control groups. All patients received routine treatment, including antiplatelet therapy, circulatory support, and symp-tomatic treatment. The study group (n=43) also received daily atorvastatin 20 mg/d, and the control group (n=46) received daily placebo pills containing glucose. After 4 weeks, the levels of C-reactive protein, fibrinogen, and D-dimer were significantly lower in the study group than in the control group. Decreases in the levels of C-reactive protein, fibrinogen, and D-dimer were not associated with de-creases in the levels of triacylglycerol and low-density lipoprotein cholesterol. These results suggest that atorvastatin reduces inflammation and thrombogenesis independent of its lipid-lowering effects in patients with acute ischemic stroke caused by large-artery atherosclerosis. 关 键 词：抗血栓 中风 缺血 急性 抗炎 动脉粥样硬化 C-反应蛋白 D-二聚体
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