Autophagy and neurodegenerative disorders

查看全文 作　　者：Evangelia [1]Kesidou;Roza [1]Lagoudaki;Olga [1]Touloumi;Kyriaki-Nefeli [1]Poulatsidou;Constantina [2]Simeonidou

机构地区：[1]Laboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki;[2]Department of Experimental Physiology, Medical School, Aristotle University of Thessaloniki

出　　处：《Neural Regeneration Research》索引2013年第8卷第24期,共9页

摘　　要：Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders. 关键词：神经退行性疾病自噬毒性作用氧化应激错误折叠神经元活性氧细胞内

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Autophagy and neurodegenerative disorders

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