S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein

查看全文 作　　者：Xue [1,2]Li;Wencong [3]Zhao;Hongqi [1,2]Yang;Junhong [1,2]Zhang;Jianjun [1,2]Ma

机构地区：[1]Department of Neurology,Henan Provincial People's Hospital;[2]Department of Neurology,People's Hospital of Zhengzhou University;[3]Department of Pharmacology,Zhengzhou Maternal and Child Health Hospital

出　　处：《Neural Regeneration Research》索引2013年第8卷第27期,共8页

基　　金：supported by grants from Henan Medical Technologies R&D Program in China,No.200703023,201203130;Henan Key Science and Technology Project in China,No.112102310684 摘　　要：Humanin is a potential therapeutic agent for Alzheimer's disease,and its derivative,S14G-humanin,is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults.Although effective,the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear.Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane,increasing intracellular calcium,generating reactive oxygen species,and decreasing the mitochondrial membrane potential.S14G-humanin restored these responses.The results suggested that S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane,and restored the disturbed cellular homeostasis,thereby exerting a neuroprotective effect on hippocampal neurons. 关键词：Β-淀粉样蛋白神经保护作用老年痴呆症稳态细胞干扰海马神经元分子机制

相关文献

参考文献（37）
引证文献（1）
耦合文献（0）

参考文献(37)

引证文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein

参考文献(37)

引证文献(1)

用户提示