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Increased Arterial Stiffness in Subjects with Pre-diabetes among Middle Aged Population in Beijing,China

查看全文 作　　者：SHEN [1]Li;ZHANG Yan [2]Ge;LIU [1]Min;WU Liu [2]Xin;QIANG Dong [2]Chang;SUN Xue [2]Lei;LIU [2]Lin;JIANG Yuan [2]Yuan 高影响力作者 机构地区：[1]Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center;[2]Institute of Aviation Medicine AF高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2013年第26卷第9期,共9页高影响力期刊 基　　金：supported by National Science & Technology Pillar Program(No.2008BAI52B03) 摘　　要：Objective To investigate the relationship between arterial stiffness and pre-diabetes when assessed by the new glycosylated hemoglobin A1c(HbA1c) 5.7%-6.4% criterion or by impaired fasting glucose in middle aged Chinese.Methods 1122 adults aged 55 years or younger in the health examination centers for physical check-ups were enrolled in the two large-sized Tertiary Comprehensive Hospitals in Beijing from June 2011 to June 2012 after excluding those who previously had been diagnosed or treated as diabetes or cardiovascular disease.Subjects with a diagnosis of pre-diabetes according to impaired fasting glucose(IFG)(fasting plasma glucose(FPG) levels at 5.6-6.9 mmol/L),HbA1c levels at 5.7%-6.4%,or both,were classified into four groups for observation:(1) Normoglycaemia(HbA1c <5.7% and FPG <5.6 mmol/L);(2) IFG alone(FPG levels at 5.6-6.9 mmol/L and HbA1c <5.7%);(3) HbA1c 5.7%-6.4% alone(HbA1c levels at 5.7%-6.4% and FPG <5.6 mmol/L);and(4) both HbA1c 5.7%-6.4% and IFG(HbA1c levels at 5.7%-6.4% and FPG levels at 5.6-6.9 mmol/L).All subjects were measured for weight,height,waist circumference,blood pressure,fasting plasma glucose,HbA1c,lipid profile and brachial-ankle pulse wave velocity(baPWV).Results The mean values of baPWV were 1282±8,1311±10,1398±30,and 1418±27 cm/s(Mean±SE) in Normoglycaemia,HbA1c 5.7%-6.4% alone,IFG alone and the both HbA1c 5.7%-6.4% and IFG groups,respectively.After adjusting for age,gender,blood pressure,BMI and triglyceride,baPWV was significantly higher in subjects with both HbA1c 5.7%-6.4% and IFG compared among the subjects with Normoglycaemia(1350±14 vs.1301±6 cm/s,P=0.002) and HbA1c 5.7%-6.4% alone(1350±14 vs.1309±8 cm/s,P=0.013).Conclusion Subjects with pre-diabetes exhibited a greater arterial stiffness. 关 键 词：糖尿病 前期 硬度 动脉 北京 中国 中年 糖化血红蛋白
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