趋化因子IL-8、MCP-1和MIP-1α在胆囊癌中表达的临床病理学意义(英文)

查看全文 作　　者：Liang [1,2]Zeng;Xiaoyan [3]Wang;Lixue [4]Zhou;Chao [4]Guo;Chunlin [5]Cai;Jinshu [4]Wu

机构地区：[1]Department of Pathology, Hunan Provincial Tumor Hospital;[2]The Affiliated Tumor Hospital of Xiangya Medicine School of Central South University;[3]Department of Rehabilitation and Dermatology, Renmin Hospital of Tulufan;[4]Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital;[5]The Forth Infection Department, The First Hospital of Changsha

出　　处：《The Chinese-German Journal of Clinical Oncology》索引2013年第12卷第10期,共6页

摘　　要：Objective: Gallbladder carcinoma was one of the malignant tumors in the digestive system, characterized by high recurrence and invasion. Recent research indicates that chemotactic factors such as IL-8, MCP-1 and MIP-1α have played an important role in such aspects as formulation, growth, shifting of the tumor. The aim of this study was to investigate expressions of IL-8, MCP-1 and MIP-1α in gallbladder adenocarcinoma tissues. Methods: Gallbladder adenocarcinoma and noncancerous tissues were routinely formalin-fixed and paraffin-embedded, and in situ hybridization assay for IL-8, MCP-1and MIP-1α mRNA. Results:(1) The positive rates or the scorings of IL-8, MCP-1 and MIP-1α mRNA were significantly higher in human gallbladder adenocarcinoma than those in human chronic cholecystitis(P < 0.01). The positive rates or the scorings of three factors were lower in well-differentiatiated gallbladder adenocarcinoma than in poorly-differenfiatted ones, whereas there was only one significant difference between MCP-1 mRNA(P < 0.05). The closely positive correlation were found among IL-8, MCP-1 and MIP-1α mRNA.(2) Both the positive rates of IL-8 mRNA and MCP-1 mRNA as well as their scorings were tightly related to their invasion of the common bile duct and the occurrence of lymph node transfer, moreover, the positive rates of MIP-1α mRNA and its scorings were tightly related to its invasion of liver.(3) Close positive correlation exists not only in IL-8 mRNA and MCP-1 mRNA(r = 0.528), but also in MIP-1α mRNA and IL-8 mRNA(r = 0.422), so does in MCP-1mRNA and MIP-1α mRNA(r = 0.638). Conclusion: The positive rates or the scorings of IL-8, MCP-1 and MIP-1α mRNA are significantly higher in human gallbladder adenocarcinoma than those in human chronic cholecystitis, and the closely positive correlation are found among them, which suggests that IL-8, MCP-1 and MIP-1α regulate and influence the development and transformation of the gallbladder adencarcinoma together. 关键词：MCP-1 IL-8 趋化因子膀胱癌胆囊炎临床病理 mRNA表达 RNA原位杂交

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趋化因子IL-8、MCP-1和MIP-1α在胆囊癌中表达的临床病理学意义(英文)

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