Design, Synthesis, and Biological Evaluation of Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase

查看全文 作　　者：Xing Gao Haojun Gong Peng Men Lu Zhou Deyong [1]Ye 机构地区：[1]Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China 出　　处：《Chinese Journal of Chemistry》索引2013年第31卷第9期,共7页 基　　金：The work was funded by the National Natural Science Foundation of China,Specialized Research Fund for the Doctoral Program of Higher Education,Chinese Ministry of Education,the open grant of the State Key Laboratory of Bio-organic and Natural Products Chemistry,CAS,and open grant of Institute of Bioscience,Fudan University 摘　　要：包含吲哚和不同长度和替换的氨基的氰化物碎片的双禁止者放的八 SMS 和 sPLA2 的一个新奇系列被综合并且评估由三在 vitro 试金不同。生物评估证明所有混合物对 SMS 提供了禁止的效果(在 100 点的大约 50% 抑制 ??遰 吗?? 关 键 词：生物评价 合成酶 抑制剂 磷脂酶A2 鞘磷脂 分泌型 设计 神经