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Regional gray matter atrophy and neuropsychologcal problems in relapsing-remitting multiple sclerosis

查看全文 作　　者：Aiyu [1]Lin;Fuyong [2]Chen;Fang [3]Liu;Zhiwen [1]Li;Ying [4]Liu;Shifang [1]Lin;Xiaoyi [2]Wang;Jiting [1]Zhu 高影响力作者 机构地区：[1]Department of Neurology, the First Affiliated Hospital of Fujian Medical University;[2]Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University;[3]Department of Hyperbaric Oxygen Treatment, the First Affiliated Hospital of Fujian Medical University;[4]Department of Radiology, The First Affiliated Hospital of Fujian Medical University高影响力机构 出　　处：《Neural Regeneration Research》索引2013年第8卷第21期,共8页高影响力期刊 摘　　要：In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered. It has been conjectured that focal atrophy is associated with emotional decline. However, conventional MRI has revealed that the pathological characteristics cannot fully account for the mood disorders. Moreover, there is no correlation between cognitive disorders and MRI results in clinically isolated syndromes or in cases of definite multiple sclerosis. In this casecontrol study, voxel-based morphometric analysis was performed on 11 subjects with relapsing-remitting multiple sclerosis, and the results show that these patients exhibit gray matter atrophy. Moreover, the gray matter atrophy in the superior and middle gyri of the right frontal lobe in patients with multiple sclerosis was correlated with scores from the Hamilton Anxiety Rating Scale. The scores obtained with the Repeatable Battery for the Assessment of Neuropsychological Status were associated with gray matter atrophy in the middle gyrus of the left frontal lobe, the superior and middle gyrus of the right frontal lobe, the middle gyrus of the left cingulate, the superior and middle gyri of the left frontal lobe, and the triangular area of the left frontal lobe. However, there was no statistical significance. These findings suggest that the cingulate and frontal cortices of the dominant hemisphere are the most severely atrophic regions of the brain, and this atrophy is correlated with cognitive decline and emotional abnormalities. 关 键 词：多发性硬化 灰质 复发 额叶皮层 认知障碍 三角形区域 病理特征 临床分离
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