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Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines

查看全文 作  者:TAN [1]Long;SANG Zhong [1]Na;SHEN [2]Jun;WU Yun [1]Tang;YAO Zhai [1]Xiao;ZHANG Jin [1]Xiang;ZHAO [1]Na;ZHANG Wan [1]Qi 高影响力作者 机构地区:[1]Nutrition and Food Security Department, College of Public Health, Tianjin Medical University, 22 Qixiangtai Road,Heping District;[2]Sanitary Chemistry Department, College of Public Health, Tianjin Medical University, 22 Qixiangtai Road,Heping District高影响力机构 出  处:《Biomedical and Environmental Sciences》索引2013年第26卷第11期,共6页高影响力期刊 基  金:supported by three programs from the National Natural Science Foundation of China (NSFC) (The experimental study on the effect of trace elements iodine and selenium on the autoimmune thyroid disease (No.30571564);The cross-sectional investigation on hypothyroidism induced by excess iodine intake and the experimental research on pathogenesy (No.30972465);The change of thyroid pathology and the levels of T3,T4 in SePP1,GPX3 knock out mice (No.30810103004) 摘  要:Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the 关 键 词:自身免疫性疾病 甲状腺疾病 细胞因子 缓解作用 2型 微量元素 发病机制
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